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A level Biology B · Edexcel 9BI0 · Topic 8C

Population genetics

Key points

  • A gene pool is all the alleles in a population; allele frequency is the proportion of a particular allele.
  • Hardy–Weinberg: p+q=1p + q = 1 and p2+2pq+q2=1p^2 + 2pq + q^2 = 1, where pp and qq are the frequencies of the dominant and recessive alleles.
  • Typical exam step: work out q2q^2 from the number of homozygous recessive individuals, take the square root to get qq, then p=1−qp = 1 - q and carriers = 2pq2pq.
  • The principle assumes a large population, random mating, no mutation, no migration and no selection.
  • Genetic drift: random changes in allele frequency, strongest in small populations.
  • Founder effect (a few individuals start a new population) and genetic bottleneck (a population crashes) both reduce genetic diversity.

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Evolution happens in populations, not individuals. Population genetics tracks how common each allele is and explains why those frequencies change from one generation to the next.

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